David Davies: Structural biologist and mentor

Professor David Y. Graham: A Brilliant Scientist and a Compassionate Mentor

 There is an enormous number of astounding scientists, who have made their mark in science. Very few of them also serve as a true mentor, ready to provide a helping hand to young researchers, especially those in developing countries, who must constantly struggle to remain optimistic. Professor David Y. Graham is one of these rare characters. He received his undergraduate degree from the U...

Interactive visualization tools for the structural biologist

In structural biology, management of a large number of Protein Data Bank (PDB) files and raw X-ray diffraction images often presents a major organizational problem. Existing software packages that manipulate these file types were not designed for these kinds of file-management tasks. This is typically encountered when browsing through a folder of hundreds of X-ray images, with the aim of rapidl...

More hydrogen bonds for the (structural) biologist.

Why does a given protein structure form and why is this structure stable? These fundamental biochemical questions remain fascinating and challenging problems because the physical bases of the forces that govern protein structure, stability and folding are still not well understood. Now, a general concept of hydrogen bonding in proteins is emerging. This concept involves not only N-H and O-H don...

Gene3D: structural assignments for the biologist and bioinformaticist alike

The Gene3D database (http://www.biochem.ucl.ac.uk/bsm/cath_new/Gene3D/) provides structural assignments for genes within complete genomes. These are available via the internet from either the World Wide Web or FTP. Assignments are made using PSI-BLAST and subsequently processed using the DRange protocol. The DRange protocol is an empirically benchmarked method for assessing the validity of stru...

Structural genomics: a pipeline for providing structures for the biologist.